Natural therapeutics: Difference between revisions

Nature provides us with many healing agents but these are often pushed to the periphery of public knowledge to ensure big pharma profits.  

= Alzheimer's =

== Antibiotic blackberries  ==

[[File:Ripe,_ripening,_and_green_blackberries.jpg|right|thumb|240px|Ripe, ripening and raw [[w:blackberries|blackberries]]]]

== Antibiotic cannabis leaves ==

* [https://www.newshub.co.nz/home/lifestyle/2019/08/woman-who-uses-cannabis-to-treat-arthritis-urges-doctors-to-prescribe-to-patients-in-need.html 'Woman who uses cannabis to treat arthritis urges doctors to prescribe to patients in need'] a 2019 article on newshub.co.nz

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= Cancers =

== Cancers and cannabis ==

'''See also: [[#Cancers and turmeric|Cancers and turmeric]]''' (intra-article link)

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== Brain cancer ==

* [https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-11-129 'Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells'], a 2011 in vitro study

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== Cervical cancer ==

* [https://www.calgarycmmc.com/cancercolorectal.htm Extensive compendium of research about colon cancer and cannabis at calgarycmmc.com]

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== Langerhans cell sarcoma ==

=== Leukemia and cannabis ===

* [https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-2029-8 Dronabinol (synthetic THC) has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns]

* [http://ar.iiarjournals.org/content/33/10/4373.abstract#corresp-1 Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules], a 2013 study published in the journal Anticancer Research  

=== Lymphoid leukemia and cannabis ===

* https://ocgreenrelief.org/medical-marijuana/cannabis-oil-acute-leukemia-2

* http://truemedmd.com/2014/06/cannabis-oil-acute-leukemia/

=== Myeloid leukemia and cannabis ===

* https://medijane.co.za/disease-index/will-marijuana-cure-cancer/acute-myeloid-leukemia-aml-cannabis/

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== Liver cancer ==

* [https://abcnews.go.com/Health/Healthday/story?id=4506595&page=1 Marijuana Compound May Fight Lung Cancer at abcnews.go.com]

* [https://www.dailymail.co.uk/health/article-6761503/Striking-scans-lung-cancer-patients-tumours-SHRINK-CBD-oil.html Patient taking CBD oil found to have significant shrinking of the tumor] (2019 article)

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* [https://www.calgarycmmc.com/ovariancancer.htm Extensive compendium of research on ovarian cancer and cannabis at calgarycmmc.com]

=== Ovarian cancer and frankincense ===

''' Links to articles about frankincense healing ''''

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== Pancreatic cancer ==

=== Pancreatic cancer and cannabis ===

* [https://www.nature.com/articles/s41388-018-0390-1 'GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine'], a 2018 study published in [[w:Oncogene (journal)|Oncogene]]. Forbes.com news item on the study [https://www.forbes.com/sites/daviddisalvo/2018/07/31/study-cbd-from-marijuana-plus-chemotherapy-triples-cancer-survival-rates-in-mice/ 'Study: CBD From Marijuana Plus Chemotherapy Tripled Cancer Survival Rates In Mice']  

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* [https://www.calgarycmmc.com/cancerprostate.htm Extensive compendium of research on prostate cancer and cannabis at calgarycmmc.com]

* https://cannabishealthradio.com/blog/2017/09/18/episode-217-his-incurable-prostate-cancer-has-been-cleared-with-the-use-of-cannabis-oil/

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== Skin cancer ==

== Melanoma ==

* [https://www.calgarycmmc.com/cancermelanoma.htm Extensive compendium of research on melanoma and cannabis at calgarycmmc.com]

* https://herb.co/learn/skin-cancer/

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= Crohn's disease =

== Crohn's disease and cannabis ==

* https://theheartysoul.com/cannabis-crohns-disease-treatment-remission/

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== Epilepsy and cannabis ==

[[File:FullExtractCannabisOil.jpg|thumb|right|360px|Full extract cannabis oil in a syringe for easy dosing and travel is usually administered in drops to the gums or under the tongue.]]

''' Studies about epilepsies and cannabis'''

* [https://www.frontiersin.org/articles/10.3389/fnint.2018.00051/full#h3 'Cannabis Therapeutics and the Future of Neurology: Cannabis and Epilepsy], a 2018 article

''' Links about epilepsies and cannabis '''

* http://www.rosintech.com/how-cannabis-concentrates-can-help-those-with-epilepsy/

'''[[w:Dravet syndrome]]''', previously known as severe myoclonic epilepsy of infancy (SMEI), is a type of [[w:epilepsy]] with seizures that are often triggered by hot temperatures or [[w:fever]].

In a 2018 trial '''[https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.621 'A prospective open‐label trial of a CBD/THC cannabis oil in dravet syndrome']''' the reasearchers found that when treating Dravet syndrome with 50:1 CBD:THC-ratio oil "There was a statistically significant improvement in quality of life, reduction in EEG spike activity, and median '''motor seizure reduction of 70.6%''', with 50% responder rate of 63%.". [https://www.ctvnews.ca/mobile/health/cannabis-oil-with-thc-may-help-treat-kids-with-severe-epilepsy-1.4035970 CTVNews.ca article 'Cannabis oil with THC may help treat kids with severe epilepsy' reporting on the study]

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== Dermatological conditions and cannabis ==

* [https://www.skintherapyletter.com/dermatology/cannabinoids-potential/ 'The Therapeutic Potential of Cannabinoids in Dermatology'], a 2018 review published in the Skin Therapy Letter.

[[#Psoriasis and cannabis]] is listed under autoimmune diseases.  

'''[[w:Dermatitis|Dermatitis]]''', also known as '''eczema''', is a group of diseases that results in [[w:inflammation|inflammation]] of the [[w:Human skin|skin]] that includes [[w:atopic dermatitis|atopic dermatitis]], [[w:allergic contact dermatitis|allergic contact dermatitis]], [[w:irritant contact dermatitis|irritant contact dermatitis]] and [[w:stasis dermatitis|stasis dermatitis]]. (Adapted from Wikipedia)

* [https://www.calgarycmmc.com/dermatitis.htm Extensive compendium of research about dermatitis and cannabis compiled by calgarycmmc.com]

* https://herb.co/guides/cbd-oil-psoriasis-eczema/

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== Migraines and cannabis ==

It has been suggested that clinical endocannabinoid deficiency syndrome (CEDS) may be causing migraines. Many studies found medical cannabis as an effective prophylaxis against migraine attacks, especially the high CBD strains.

* [https://www.frontiersin.org/articles/10.3389/fphar.2018.00420/full 'Emerging Role of (Endo)Cannabinoids in Migraine'], a 2018 mini-review, where they summarize recent discoveries and present new hypotheses on the role of cannabinoids in controlling trigeminal nociceptive system underlying migraine pain.

* [https://www.jpain.org/article/S1526-5900(19)30848-X/fulltext 'Short- and Long-Term Effects of Cannabis on Headache and Migraine'], a 2019 open access article published in [[w:The Journal of Pain|The Journal of Pain]] of the [[w:American Pain Society|American Pain Society]] placed under [https://creativecommons.org/licenses/by-nc-nd/4.0/ CC BY-NC-ND 4.0]  

''' Compediums about migraines and cannabis '''

* [http://migrainebuds.com/research-articles-on-cannabis-and-migraines/ Abstracts of studies on migraines and medical cannabis at migrainebuds.com]

* https://www.rxleaf.com/migraine-relief

{{Q|You just don't feel like thinking about the pain.|Apotheker [[User:Jukeboksi|Jukeboksi]]|somatic pain relief with cannabis}}

''' Collections of information on pain management with cannabis '''

* [https://www.calgarycmmc.com/pain.htm Extensive compendium of research about pain relief and cannabis compiled by calgarycmmc.com]

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'''Scientific studies on the issue of Parkinsons and cannabinoids'''

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== Non-somatic issues with cannabis ==

Cannabis can help with various non-somatic problems such as psychiatry, depression and [[w:PTSD|PTSD]].

* [https://www.fundacion-canna.es/en/pursuit-happiness-and-what-cannabinoids-have-do-it 'The pursuit of happiness and what cannabinoids have to do with it'], a fundacion-canna.es article by Tanja Bagar

=== Depression and cannabis ===

* [https://www.calgarycmmc.com/depression.htm Extensive compendium of research about depression and cannabis compiled by calgarycmmc.com]

=== Psychosis and cannabis ===

* [https://www.theguardian.com/science/2018/aug/29/brain-scans-show-how-cannabis-extract-may-help-people-with-psychosis 'Brain scans show how cannabis extract may help people with psychosis'] (2018) article at TheGuardian.com

=== PTSD and cannabis ===

'''Studies about medical cannabis for PTSD'''

* [https://www.rxleaf.com/endocannabinoids-treat-ptsd/ 'PTSD Linked to Pre-Existing Endocannabinoid Deficiency'], a 2019 article at RXLeaf.com

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{{Q|In medicine, '''[[w:sclerosis (medicine)|sclerosis]]'''  is the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with [[w:connective tissue|connective tissue]].|Wikipedia|Sclerosis}}

=== Amyotrophic lateral sclerosis and cannabis ===

Cannabis helps with [[w:Amyotrophic lateral sclerosis|Amyotrophic lateral sclerosis]] (ALS) also known as Lou Gehrig's disease and motor neurone disease (MND).

* [https://www.calgarycmmc.com/alsamyotrophiclatera.htm Extensive compendium of research about Amyotrophic lateral sclerosis and cannabis compiled by calgarycmmc.com]

=== Multiple sclerosis (MS) and cannabis ===

Cannabis is very good against [[w:Multiple sclerosis|Multiple sclerosis]]. Prince Charles knew of this way back in 1998<ref name="TheGuardian1998">https://www.theguardian.com/uk/1998/dec/24/monarchy.ameliagentleman</ref>.

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== Seizures and cannabis ==

* https://medium.com/@ahealthycrew/cannabis-oil-replaces-22-pills-for-little-boy-with-seizures-d0b22ea6be09

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== Strokes and cannabis ==

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== Traumatic brain injury and cannabis ==

Cannabis can help in healing from TBI

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''' Main article in wikipedia [[w:Endocannabinoid system|Endocannabinoid system]]'''

* [https://norml.org/library/item/introduction-to-the-endocannabinoid-system 'Introduction to the Endocannabinoid System'] at [[w:National Organization for the Reform of Marijuana Laws|NORML]] (.org)

* [https://www.medicinalgenomics.com/endocannabinoid-basics/ 'Endocannabinoid Basics' at MedicinalGenomics.com]

* [https://hempedification.wordpress.com/2017/08/05/endocannabinoids-beyond-the-brain/ Endocannabinoids – Beyond the Brain]  is a good 2017 article on the Hemp Edification blog] adapted from [https://www.the-scientist.com/features/your-body-is-teeming-with-weed-receptors-31233 Your Body Is Teeming with Weed Receptors, a 2017 article on the website the-scientist.com] and [https://www.the-scientist.com/multimedia/endocannabinoids-in-the-groove-31240 Endocannabinoids in the Groove, a 2017 article on the website the-scientist.com]

* http://profofpot.com/endocannabinoid-receptors/

[[File:Stock-vector-human-endocannabinoid-system-target-active-in-male-and-female-body-1237262152.jpg|thumb|right|520px|Prevalence of endocannabinoid receptors in the human body. Photo credit: [https://www.shutterstock.com/g/Thanasp ThanasStudio]]]

Human body contains 2 types of endocannabinoid [[w:Cannabinoid receptor|receptors]] [[w:Cannabinoid receptor type 1|CB₁]] and [[w:Cannabinoid receptor type 2|CB₂]], but cannabinoids have interactions also on some other receptors.

CB₁ receptors predominantly located in the nervous system, connective tissues, gonads, glands, and organs<ref name=p4mm>https://patients4medicalmarijuana.wordpress.com/2017/07/06/how-and-why-your-brain-makes-its-own-cannabinoids/</ref>.

CB₂ receptors, primarily found in the immune system and also present in the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands, and reproductive organs<ref name=p4mm/>.

[[File:Anandamid.svg|thumb|200px|[[w:Anandamide|Anandamide]], an endogenous [[w:ligand|ligand]] of CB₁ and CB₂]]

The two main endocannabinoids are Anandamide and 2-AG.

[[w:Anandamide|Anandamide]] was discovered in 1992 and it binds to both CB₁ and CB₂ receptors. The name comes from the [[w:Sanskrit|Sanskrit]] word 'Ananda' meaning 'bliss' and [[w:amide|amide]] from its chemistry.  

* [https://herb.co/marijuana/news/anandamide-aea Herb.co on Anandamide]

[[File:2-Ara-Gl.svg|thumb|right|200px|2-Arachidonoylglycerol (2-AG) is an endogenous [[w:agonist|agonist]] of the [[w:CB1 receptor|CB₁ receptor]].]]

[[w:2-Arachidonoylglycerol|2-Arachidonoylglycerol]] aka. 2-AG was discovered in 1994-1995.

'''Synthesis''' of '''2-AG''': Arachidonic acid -> [[w:Phosphatidylinositol|Phosphatidylinositol]] + [[w:Phospholipase C|Phospholipase C]]s -> [[w:Diacylglycerol]] + Diacylglycerol lipase -> [[w:2-AG|2-AG]]<ref name="EJR2017"/>

[[w:N-Arachidonoyl dopamine|N-Arachidonoyl dopamine]] discovered in 2000.

[[w:2-Arachidonyl glyceryl ether|2-Arachidonyl glyceryl ether]] discovered in 2001.

[[w:Virodhamine|Virodhamine]] discovered in 2002

[[w:Lysophosphatidylinositol|Lysophosphatidylinositol]] is a contender to be the 6th endocannabinoid.

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[[File:Cannabis indica.jpg|thumb|left|360px|Female [[w:Cannabis indica|Cannabis indica]] plants. These are often good for pain relief producing a nice body stone.]]

* [[#CBT|CBT]] (Cannabicitran)

[[File:Tetrahydrocannabinol.svg|thumb|right|200px|[[w:Tetrahydrocannabinol|Tetrahydrocannabinol]] is a partial [[w:agonist|agonist]] of [[w:Cannabinoid receptor type 1|CB₁]] located mainly in the [[w:central nervous system|central nervous system]], and the [[w:Cannabinoid receptor type 2|CB₂]] receptor mainly expressed in cells of the [[w:immune system|immune system]].]]

* [https://hightimes.com/culture/therapeutic-benefits-dabbing-delta-8-thc/ Hightimes article on Delta-8 THC]

[[w:Tetrahydrocannabinolic acid|Tetrahydrocannabinolic acid]] THCA is the what cannabis plants produce to fend off insects from harming it. In pure form THCA is a clear translucent crystalline of white color.

* https://thefreshtoast.com/cannabis/marijuanas-thc-a-as-an-anti-inflammatory-and-neuro-protectant/

[[File:Cannabidiol.svg|thumb|left|200px|[[w:Cannabidiol|Cannabidiol]] has very low [[w:affinity (pharmacology)|affinity]] for the [[w:cannabinoid receptor|cannabinoid]] [[w:Cannabinoid receptor type 1|CB₁]] and [[w:Cannabinoid receptor type 2|CB₂]] receptors  receptors but acts as an indirect [[w:receptor antagonist|antagonist]] of cannabinoid [[w:agonist|agonist]]s.]]

* [http://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf WHO preliminary report on CBD]

Cannabidiolic Acid is the raw form. Decarboxylating CBDA yields CBD.

* https://herb.co/learn/cbda/

[[w:Cannabinol|Cannabinol]] is a sleeping aid and has also other therapeutic qualities.

* https://www.medicaljane.com/2013/08/19/cannabinol-cbn-will-put-you-to-bed/

[[w:Cannabigerol|Cannabigerol]]  

* https://comparecbd.com/cbg/

[[w:Cannabichromene|Cannabichromene]]

[[w:Cannabicyclol|Cannabicyclol]]

[[w:Cannabivarin|Cannabivarin]]

[[w:Tetrahydrocannabivarin|Tetrahydrocannabivarin]] can be used to inhibit appetite.

* http://herb.co/2017/04/14/tetrahydrocannabivarin-thcv/

[[w:Cannabidivarin|Cannabidivarin]]

Cannabichromevarin

Cannabigerovarin

Cannabigerol Monomethyl Ether

Cannabielsoin

Cannabicitran

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Scientists have figured out how to splice the DNA of yeasts, so that they produce cannabinoids.<ref name="GlobalHealthTimes2019">http://globalhealthtimes.com/2019/03/06/scientists-are-making-thc-and-cbd-in-a-lab-without-growing/</ref>

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'''[[w:Cannflavin|Cannaflavins]]''' '''A''' and '''B''' are very potent anti-inflammatory agents and thus help lessen the pain sensation originating from inflammation.

''' Links about cannflavins '''

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'''Terpenes''' are a large and diverse [[w:Organic chemistry#Classification of organic compounds|class]] of [[w:organic compound|organic compound]]s, produced by a variety of [[w:plant|plant]]s, particularly [[w:Pinophyta|conifers]], and by some [[w:insect]]s.<ref name=book>{{cite book|title=Terpenes: Flavors, Fragrances, Pharmaca, Pheromones|author=Eberhard Breitmaier|year= 2006|isbn=9783527609949 |doi=10.1002/9783527609949|publisher=Wiley-VCH}}</ref>

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'''[[w:Synthetic cannabinoids|Synthetic cannabinoids]]''' are a class of molecules that [[w:Binding affinity|bind]] to [[w:cannabinoid receptor|cannabinoid receptor]]s in the body — the same receptors to which [[w:Tetrahydrocannabinol|THC]] and [[w:Cannabidiol|CBD]] attach – which are [[w:cannabinoid|cannabinoid]]s in [[w:cannabis|cannabis]] plants. (Wikipedia)

'''[[w:Arachidonyl-2'-chloroethylamide|Arachidonyl-2'-chloroethylamide]]''' (ACEA) is a synthetic agonist of the [[w:Cannabinoid receptor type 1|CB₁]] receptor. (Wikipedia)

# '''[[w:Echinacea|Echinacea]]''' contains N-alkyl[[w:amide|amide]]s, that function via cannabimemetics to provide immune-boosting and is also used to relieve anxiety, fatigue, migraines and arthritis.<ref name="LLF2018">https://livelovefruit.com/8-non-marijuana-plants-contain-cannabinoids/</ref>

# '''[[w:Black pepper|Black pepper]]''' contains high levels of the [[w:terpene|terpene]] called [[w:Caryophyllene|β-caryophyllene]] (BCP). BCP functions as a cannabinoid, and has a binding affinity with the CB₂ receptor.<ref name="LLF2018"/>

* https://livelovefruit.com/8-non-marijuana-plants-contain-cannabinoids/

* https://www.marijuana.com/news/2017/05/9-plants-that-contain-therapeutic-cannabinoids/

== Administering cannabis ==

* https://canna-lance.com/2018/08/27/did-you-know-you-could-consume-cannabis-like-this/

* https://www.portlandmercury.com/blogtown/2019/07/17/26809203/a-new-way-to-consume-cannabis-through-your-belly-button

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* [http://www.greenmedinfo.com/ GreenMedinfo - The Science of Natural Healing]

* [https://www.healthline.com/ HealthLine.com contains a myriad of information about different medical conditions and in addition to having info on conditions and natural therapeutics it also covers main stream medications]

* https://herbalremediesbook.com/

* https://livelovefruit.com/ is excellent website on health tips / natural therapeutics by Carly Fraser, a professional in the field.

= References =

<references/>