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(→The endocannbinoid system: + Synthesis of 2-AG: Arachidonic acid -> w:Phosphatidylinositol + w:Phospholipase Cs -> w:Diacylglycerol + Diacylglycerol lipase -> 2-AG<ref name="EJR2017"/>) |
(→The endocannabinoid system: moved the syntheses under the endocannabinoid being synthesized) |
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Endocannabinoids are produced by our own bodies from [[w:Arachidonic acid|Arachidonic acid]], an [[w:Omega-6 fatty acid|Omega-6 fatty acid]]<ref name=wakeup-world-com>https://wakeup-world.com/2014/09/08/the-endocannabinoid-system-and-how-thc-cures-cancer/</ref>. | Endocannabinoids are produced by our own bodies from [[w:Arachidonic acid|Arachidonic acid]], an [[w:Omega-6 fatty acid|Omega-6 fatty acid]]<ref name=wakeup-world-com>https://wakeup-world.com/2014/09/08/the-endocannabinoid-system-and-how-thc-cures-cancer/</ref>. | ||
'''Articles about the endocannabinoid system''' | '''Articles about the endocannabinoid system''' | ||
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It has been referred to as the endocannabinoid version of THC. | It has been referred to as the endocannabinoid version of THC. | ||
'''Synthesis''' of '''Anandamide''': Arachidonic acid -> Phosphatidylethanolamide + N-[[w:Acyltransferase|Acyltransferase]] -> N-arachidonoyl phosphatidylethanolamine + [[w:Phospholipase D|Phospholipase D]] -> [[w:Anandamide|Anandamide]]<ref name="EJR2017">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685274/</ref> | |||
* [https://herb.co/marijuana/news/anandamide-aea Herb.co on Anandamide] | * [https://herb.co/marijuana/news/anandamide-aea Herb.co on Anandamide] | ||
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[[File:2-Ara-Gl.svg|thumb|right|200px|2-Arachidonoylglycerol (2-AG) is an endogenous [[w:agonist|agonist]] of the [[w:CB1 receptor|CB<sub>1</sub> receptor]].]] | [[File:2-Ara-Gl.svg|thumb|right|200px|2-Arachidonoylglycerol (2-AG) is an endogenous [[w:agonist|agonist]] of the [[w:CB1 receptor|CB<sub>1</sub> receptor]].]] | ||
[[w:2-Arachidonoylglycerol|2-Arachidonoylglycerol]] aka. 2-AG was discovered in 1994-1995. | [[w:2-Arachidonoylglycerol|2-Arachidonoylglycerol]] aka. 2-AG was discovered in 1994-1995. | ||
'''Synthesis''' of '''2-AG''': Arachidonic acid -> [[w:Phosphatidylinositol|Phosphatidylinositol]] + [[w:Phospholipase C|Phospholipase C]]s -> [[w:Diacylglycerol]] + Diacylglycerol lipase -> [[w:2-AG|2-AG]]<ref name="EJR2017"/> | |||
==== N-Arachidonoyl dopamine ==== | ==== N-Arachidonoyl dopamine ==== |